Feasibility of lifestyle interventions for cognition in adults with low education

• DOI: 10.1002/alz.70232
• Publication Date: 2025-05-30T03:53:50Z
• Authors: Daniel O. Clark; Huiping Xu; Christy C. Tangney; Annie W. Lin; Shannon L. Risacher; Andrew J. Saykin; Robert V. Considine; Holly J. Garringer; Lyndsi Moser; Amy Carter; Catherine M. Miller; Briana Sprague; Christopher M. Ca...; Frederick W. Unve...
• Keywords: Cognitive Training; Cognitive Decline; Nutrition Education

Abstract INTRODUCTION We report the feasibility and cognitive outcomes of a stage 1b randomized trial testing 3 months home‐delivered high polyphenol snacks (e.g., nuts, berries) online speed processing training among older adults with 12 or fewer years education. METHODS One hundred eighty participants were to polyphenol‐rich training, control games, games. The recruitment, retention, adherence (RRA) change in composite score. RESULTS Feasibility goals for RRA met. Improvements score evident all groups (effect sizes ranged from 0.15–0.35) but improvements did not differ significantly between arms. DISCUSSION Dementia prevention trials longer intervention follow‐up focused on limited formal education should be considered given observed gains those elevated risk. Clinical Trial Registration: ClinicalTrials.gov (NCT03419052). Highlights study low education; group risk decline. Two interventions tested design that included two controls. Nutrition was designed input Primary outcome: A formed five established tests. establishes dementia targeting