A susceptibility gene for late‐onset idiopathic Parkinson's disease

• DOI: 10.1002/ana.10324
• Publication Date: 2002-10-28T14:33:34Z
• Authors: Andrew A. Hicks; Hjörvar Pétursson; Thorlákur Jónsson; Hreinn Stefánsson; Hrefna S. Jóhanns...; Jesus Sainz; Michael L. Frigge; Augustine Kong; Jeffrey R. Gulcher; Kári Stefánsson; Sigurlaug Sveinbj...
• Keywords: Genetic linkage

Abstract Eight regions of the genome ( PARK1‐8 ) have been implicated in autosomal dominant and recessive forms early‐onset Parkinson's disease. These constitute a few all cases. However, except for haplotype six families PARK3 ), no study has successfully mapped gene or described mutations that contribute to common late‐onset Some even suggested genetic component does not exist. We cross‐matched our nationwide genealogy database with population‐based list Icelandic disease patients search more than one patient. performed genomewide scan on 117 168 their unaffected relatives within 51 using 781 microsatellite markers. Allele‐sharing, model‐independent analysis results showed linkage region chromosome 1p32 logarithm odds score 3.9 (Z lr = 4.2). By increasing information content additional markers this region, we found increased 4.9 4.8). This result corresponds an unadjusted p value 1.0 × 10 −6 < 0.005 after adjusting search. designate PARK10 . therefore mapped, significance, susceptibility multiple drawn across whole population. Identification may pave way better understanding process, which, turn, lead improved diagnostics therapeutics.