Sex differences in cell death

• DOI: 10.1002/ana.20538
• Publication Date: 2005-06-29T21:16:55Z
• Authors: Hong Li; Scott Pin; Zhiyuan Zeng; Michael M. Wang; Katrin A. Andreasson; Louise D. McCullough
• Keywords: Stroke

Abstract Female patients experience substantial neuroprotection after experimental stroke compared with male patients, a finding attributed to the protective effects of gonadal hormones. This study examined response male‐ and female‐derived organotypic hippocampal slices oxidative excitotoxic injury. Both oxygen glucose deprivation N ‐methyl‐ D ‐aspartic acid exposure led neuronal death; however, cultures sustained less injury than male‐derived cultures. Cell death was ameliorated in cultures, but not female by addition 7‐nitroindazole, nitric oxide synthase inhibitor. These studies have relevance researchers investigating neuroprotective agents mixed sex experiments. Ann Neurol 2005