Detection of isolated cerebrovascular β‐amyloid with pittsburgh compound B

• DOI: 10.1002/ana.21528
• Publication Date: 2008-12-10T01:06:25Z
• Authors: Steven M. Greenberg; Thomas Grabowski; M. Edip Gurol; Maureen E. Skehan; R. N. Kaveer Nand...; John A. Becker; Monica Garcia‐Alloza; Claudia Prada; Matthew P. Frosch; Jonathan Rosand; Anand Viswanathan; Eric E. Smith; Keith A. Johnson
• Keywords: Pittsburgh compound B; Amyloid (mycology); Angiopathy

Abstract Imaging of cerebrovascular β‐amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging Pittsburgh Compound B on 42‐year‐old man early manifestations Iowa‐type hereditary cerebral angiopathy, a form disorder little or no plaque deposits fibrillar β‐amyloid. The results demonstrated increased retention selectively in occipital cortex, sparing regions typically labeled disease. These offer compelling evidence that tomography can noninvasively detect isolated angiopathy before overt signs tissue damage such as hemorrhage white matter lesions. Ann Neurol 2008;64:587–591