Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study

• DOI: 10.1002/ana.24081
• Publication Date: 2013-12-07T11:51:21Z
• Authors: Darrell V. Lewis; Shlomo Shinnar; Dale C. Hesdorffer; Emilia Bagiella; Jacqueline A. Bello; Stephen Chan; Yuan Xu; James MacFall; William A. Gomes; Solomon L. Moshé; Gary W. Mathern; John M. Pellock; Douglas R. Nordli; L. Matthew Frank; James Provenzale; Ruth C. Shinnar; Leon G. Epstein; David Masur; Claire Litherland; Shumei Sun
• Keywords: Hippocampal sclerosis

Whether febrile status epilepticus (FSE) produces hippocampal sclerosis (HS) and temporal lobe epilepsy (TLE) has long been debated. Our objective is to determine whether FSE acute injury that evolves HS.FEBSTAT 2 affiliated studies prospectively recruited 226 children aged 1 month 6 years with controls simple seizures. All had magnetic resonance imaging (MRI), follow-up MRI was obtained approximately year later in the majority. Visual interpretation by neuroradiologists informed only of subject age augmented volumetrics, analysis intrahippocampal distribution T2 signal, apparent diffusion coefficients.Hippocampal hyperintensity, maximum Sommer's sector, occurred acutely after 22 association increased volume. Follow-up on 14 hyperintensity showed HS 10 reduced volume 12. In contrast, 116 without abnormal signal (following another episode FSE). Furthermore, compared seizures, subjects normal abnormally low right left ratios, smaller hippocampi initially, growth.Hippocampal represents often evolving a radiological appearance year. impaired growth normal-appearing suggests subtle even absence hyperintensity. Longer needed relationship these findings TLE.