Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge Leiodermatium sp.

• DOI: 10.1002/ange.201007719
• Publication Date: 2011-03-04T09:46:20Z
• Authors: Ian Paterson; Stephen M. Dalby; Jill C. Roberts; Guy J. Naylor; Esther A. Guzmán; Richard Isbrucker; Tara P. Pitts; Pat Linley; Daniela Divlianska; John K. Reed; Amy E. Wright
• Keywords: Molecular Structure; Oceans and Seas; Mitosis; Antimitotic Agents; 01 natural sciences; Porifera; 3. Good health; 0104 chemical sciences; Cell Line, Tumor; Animals; Macrolides; Nuclear Magnetic Resonance, Biomolecular; Cell Proliferation

Leiodermatolide is a structurally unique macrolide, isolated from the deep-water marine sponge Leiodermatium sp., which exhibits potent antiproliferative activity against a range of human cancer cell lines (IC50 <10 nM) and dramatic effects on spindle formation in mitotic cells. Its unprecedented polyketide skeleton and stereochemistry were established using a combination of experimental and computational (DP4) NMR methods, and molecular modelling.