Tuning Chemoselectivity in Iron‐Catalyzed Sonogashira‐Type Reactions Using a Bisphosphine Ligand with Peripheral Steric Bulk: Selective Alkynylation of Nonactivated Alkyl Halides

• DOI: 10.1002/ange.201104125
• Publication Date: 2011-09-01T18:59:22Z
• Authors: Takuji Hatakeyama; Yoshihiro Okada; Yuya Yoshimoto; Masaharu Nakamura
• Keywords: Alkynylation; Chemoselectivity; Sonogashira coupling; Grignard reaction

Sterisch abgeschirmt: Der Eisen-Phosphan-Komplex 1 vermittelt eine hoch C-selektive Alkinylierung nichtaktivierter Alkylhalogenide mit entsprechenden Grignard-Reagentien. Primäre und sekundäre Alkyliodide, -bromide -chloride liefern in guten Ausbeuten die substituierten Alkine, anschließend Cyclisierungen Kreuzkupplungen eingehen können. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher is responsible for content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.