Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides

• DOI: 10.1002/ange.201203843
• Publication Date: 2012-09-12T01:50:26Z
• Authors: Ge‐Min Fang; Jia‐Xing Wang; Lei Liu
• Keywords: Native chemical ligation

Rasche Vereinigung: Eine allgemein anwendbare Strategie für die konvergente chemische Synthese von Proteinen aus Peptidsegmenten wurde entwickelt. Die Peptidhydrazid-Zwischenstufen können kostengünstig hergestellt werden, und neue zur des 142 Aminosäuren langen Modellproteins RpS25 sechs eingesetzt. PG=Schutzgruppe. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher is responsible for content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.