A Catalytic Asymmetric Ring‐Expansion Reaction of Isatins and α‐Alkyl‐α‐Diazoesters: Highly Efficient Synthesis of Functionalized 2‐Quinolone Derivatives

• DOI: 10.1002/ange.201204594
• Publication Date: 2012-07-23T06:35:14Z
• Authors: Wei Li; Xiaohua Liu; Xiaoyu Hao; Yunfei Cai; Lili Lin; Xiaoming Feng
• Keywords: Schema (genetic algorithms)

Asymmetrische Expansion: Ein Sc(OTf)3-Katalysator mit einem N,N′-Dioxid-basierten Liganden bewirkt die katalytische asymmetrische Ringerweiterung der Titelverbindungen. Dabei werden unter milden Reaktionsbedingungen hoch funktionalisierte 2-Chinolone chiralen quartären C4-Stereozentrum in hoher Ausbeute und Selektivität erhalten (siehe Schema; Tf=Trifluormethansulfonyl). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher is responsible for content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.