Ruthenium‐Catalyzed Reductive Methylation of Imines Using Carbon Dioxide and Molecular Hydrogen

• DOI: 10.1002/ange.201403711
• Publication Date: 2014-08-21T23:43:42Z
• Authors: Kassem Beydoun; Ghazi Ghattas; Katharina Thenert; Jürgen Klankermayer; Walter Leitner
• Keywords: Reducing agent; Triphos; Hydrogen molecule

Abstract The use of the well‐defined [Ru(triphos)(tmm)] catalyst, CO 2 as C 1 source, and H reducing agent enabled reductive methylation isolated imines, well direct coupling amines with aldehydes subsequent in situ formed imines. method, which afforded corresponding N‐methyl very good to excellent yields, was also used for preparation antifungal butenafine one step no apparent waste, thus increasing atom efficiency its synthesis.