Synthesis and Evaluation of GdIII‐Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate‐Specific Membrane Antigen

• DOI: 10.1002/ange.201503417
• Publication Date: 2015-07-24T19:52:31Z
• Authors: Sangeeta Ray Bane...; Ethel J. Ngen; Matthew W. Rotz; Samata Kakkad; Ala Lisok; Richard Pracitto; Mrudula Pullambhatla; Zhengping Chen; Tariq Shah; Dmitri Artemov; Thomas J. Meade; Zaver M. Bhujwalla; Martin G. Pomper
• Keywords: Molecular Imaging; Glutamate carboxypeptidase II

Abstract Magnetic resonance (MR) imaging is advantageous because it concurrently provides anatomic, functional, and molecular information. MR can combine the high spatial resolution of this established clinical modality with profiling in vivo. However, as a result intrinsically low sensitivity imaging, local concentrations biological targets are required to generate discernable contrast. We hypothesize that prostate‐specific membrane antigen (PSMA), an attractive target for therapy prostate cancer, could serve suitable biomarker MR‐based imaging. have synthesized three new high‐affinity, low‐molecular‐weight Gd III ‐based PSMA‐targeted contrast agents containing one chelates per molecule. evaluated relaxometric properties these solution, cancer cells, vivo experimental model demonstrate feasibility PSMA‐based