Ceria–Zirconia Nanoparticles as an Enhanced Multi‐Antioxidant for Sepsis Treatment

• DOI: 10.1002/ange.201704904
• Publication Date: 2017-06-23T10:52:57Z
• Authors: Min Soh; Dong‐Wan Kang; Han‐Gil Jeong; Dokyoon Kim; Do Yeon Kim; Wookjin Yang; Changyeong Song; Seungmin Baik; In‐Young Choi; Seul‐Ki Ki; Hyek Jin Kwon; Taeho Kim; Chi Kyung Kim; Seung‐Hoon Lee; Taeghwan Hyeon
• Keywords: Lipopolysaccharides; Cell Death; Anti-Inflammatory Agents, Non-Steroidal; Cerium; 01 natural sciences; Antioxidants; Rats; 0104 chemical sciences; 3. Good health; Mice; RAW 264.7 Cells; Sepsis; Animals; Nanoparticles; Zirconium

AbstractThe two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2− and .OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS‐related inflammatory diseases.