H2S‐Activable MOF Nanoparticle Photosensitizer for Effective Photodynamic Therapy against Cancer with Controllable Singlet‐Oxygen Release

• DOI: 10.1002/ange.201708005
• Publication Date: 2017-08-31T08:49:54Z
• Authors: Yu Ma; Xiangyuan Li; Aijie Li; Peng Yang; Caiyun Zhang; Bo Tang
• Keywords: Photosensitizing Agents; Singlet Oxygen; Metalloporphyrins; Mice, Nude; Hep G2 Cells; HCT116 Cells; 01 natural sciences; 0104 chemical sciences; 3. Good health; Photochemotherapy; Cell Line, Tumor; Neoplasms; Tumor Microenvironment; Animals; Humans; Nanoparticles; Hydrogen Sulfide

Abstract Photodynamic therapy (PDT) has emerged as an important minimally invasive tumor treatment technology. The search for effective photosensitizer to realize selective cancer become one of the major foci in recent developments PDT Controllable singlet‐oxygen release based on specific cancer‐associated events, another layer selectivity mode, attracted great attention years. Here, first time, we demonstrated that a novel mixed‐metal metal–organic framework nanoparticle (MOF NP) can be activated by hydrogen sulfide (H 2 S) signaling molecule microenvironment against with controllable living cells. removal tumors vivo further confirmed satisfactory effect MOF NP photosensitizer.