The Buchwald–Hartwig Amination After 25 Years

• DOI: 10.1002/ange.201904795
• Publication Date: 2019-06-05T14:19:29Z
• Authors: Ruth Dorel; Christian P. Grugel; Alexander M. Haydl
• Keywords: Coupling reaction; Scope (computer science)

Abstract The Pd‐catalyzed coupling of aryl (pseudo)halides and amines is one the most powerful approaches for formation C(sp 2 )−N bonds. pioneering reports from Migita subsequently Buchwald Hartwig on aminostannanes bromides rapidly evolved into general practical tin‐free protocols with broad substrate scope, which led to establishment what now known as Buchwald–Hartwig amination. This Minireview summarizes evolution this cross‐coupling reaction over course past 25 years illustrates some recent applications well‐established methodology.