Paper‐Based Ratiometric Fluorescence Analytical Devices towards Point‐of‐Care Testing of Human Serum Albumin

• DOI: 10.1002/ange.201915046
• Publication Date: 2019-12-13T11:54:12Z
• Authors: Zijie Luo; Taoyuze Lv; Kangning Zhu; Yi Li; Lei Wang; J. Justin Gooding; Guozhen Liu; Bin Liu
• Keywords: Human serum albumin; Point-of-Care Testing; Point of care; Human blood

Abstract Monitoring of human serum albumin (HSA) in a point‐of‐care fashion is urgently needed particular for elderly or chronically ill patients. Herein, dual‐state emissive chalcone probe having the feature aggregation‐induced emission was designed and synthesized. The concentration HSA can be evaluated by ratios from probes aggregated monomeric state, which gives visually discernible red‐to‐green color change. A simple, portable paper‐based analytical device have been fabricated integration recognition detection pad employed test using whole blood samples. This assay shows capability comparable to standard testing methods but fashion, providing promising tool at‐home HSA‐related disease diagnosis.