Rhodium(III)‐Catalyzed Synthesis of Skipped Enynes via C(sp3)–H Alkynylation of Terminal Alkenes

• DOI: 10.1002/ange.202014877
• Publication Date: 2021-01-10T10:27:18Z
• Authors: Franco Della‐Felice; Margherita Zanini; Xiaoming Jie; Eric Tan; Antonio M. Echava...
• Keywords: Alkynylation

Abstract The Rh III ‐catalyzed allylic C−H alkynylation of non‐activated terminal alkenes leads selectively to linear 1,4‐enynes at room‐temperature. catalytic system tolerates a wide range functional groups without competing functionalization other positions. Similarly, the vinylic α,β‐ and β,γ‐ unsaturated amides gives conjugated Z‐1,3‐enynes E‐enediynes.