Thiol‐Disulfide Exchange as a Route for Endosomal Escape of Polymeric Nanoparticles

• DOI: 10.1002/ange.202209227
• Publication Date: 2022-07-22T14:00:39Z
• Authors: Pintu Kanjilal; Kingshuk Dutta; S Thayumanavan
• Keywords: Thiol; Cross-Presentation

Abstract Endosomal entrapment has remained the major bottleneck for cytosolic delivery of nanoparticle‐based systems. Uncovering fundamentally new pathways endosomal escape is therefore highly sought. Herein, we report that disulfide bonds can enhance through contacts with cellular exofacial thiols, in addition to facilitating uptake. Our results are supported comparative analysis polymeric nanogels variable accessibility by placing these functionalities at core or shell nanogels. The findings here inform future chemical design vehicles.