Asymmetric Hydrophosphinylation of Alkynes: Facile Access to Axially Chiral Styrene‐Phosphines

• DOI: 10.1002/ange.202215820
• Publication Date: 2022-11-25T03:52:46Z
• Authors: Baohua Cai; Yuan Cui; Jian Zhou; Yong‐Bin Wang; Limin Yang; Bin Tan; Jun (Joelle) Wang
• Keywords: Axial symmetry

Abstract A Cu/CPA co‐catalytic system has been developed for achieving the direct hydrophosphinylation of alkynes with phosphine oxides in delivering novel axially chiral phosphorus‐containing alkenes high yields and excellent enantioselectivities (up to 99 % yield ee). DFT calculations were performed elucidate reaction pathway origin enantiocontrol. This streamlined modular methodology establishes a new platform design application styrene‐phosphine ligands.