Missing‐Linker‐Confined Single‐Atomic Pt Nanozymes for Enzymatic Theranostics of Tumor

• DOI: 10.1002/ange.202217995
• Publication Date: 2023-03-10T10:15:42Z
• Authors: Dongdong Wang; Lei Zhang; Changlai Wang; Zhiyu Cheng; Wei Zheng; Pengping Xu; Qianwang Chen; Yanli Zhao
• Keywords: Linker

Abstract Conventional nanozymes often possess low active site density. Pursuing effective strategies for constructing highly single‐atomic nanosystems with maximum atom utilization efficiency is exceptionally attractive. Herein, we develop a facile “missing‐linker‐confined coordination” strategy to fabricate two self‐assembled nanozymes, i.e., conventional nanozyme (NE) and (SAE), which respectively consist of Pt nanoparticles single atoms as catalytic sites anchored in metal–organic frameworks (MOFs) encapsulated photosensitizers catalase‐mimicking enhanced photodynamic therapy. Compared nanoparticle‐based nanozyme, shows activity generating oxygen overcoming tumor hypoxia, thus exhibiting more efficient reactive species generation high inhibition rate.