Synthesis of P‐Stereogenic Phosphine Oxides via Nickel‐Catalyzed Asymmetric Cross‐Coupling of Secondary Phosphine Oxides with Alkenyl and Aryl Bromides
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DOI:
10.1002/ange.202300011
Publication Date:
2023-02-14T11:29:38Z
AUTHORS (7)
ABSTRACT
Abstract A general and mild nickel‐catalyzed enantioselective C(sp 2 )−P cross‐coupling for synthesizing P‐stereogenic phosphine oxides has been developed. The asymmetric alkenylation/arylation of racemic secondary with alkenyl/aryl bromides generated high yields enantioselectivities. Various functional groups were tolerated, the applications this method demonstrated through late‐stage functionalization product transformations.
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