Synthesis of P‐Stereogenic Phosphine Oxides via Nickel‐Catalyzed Asymmetric Cross‐Coupling of Secondary Phosphine Oxides with Alkenyl and Aryl Bromides

• DOI: 10.1002/ange.202300011
• Publication Date: 2023-02-14T11:29:38Z
• Authors: Chuanyong Wang; Xiaobo Hu; Cheng Xu; Qiangqiang Ge; Qingliang Yang; Jianqi Xiong; Wei‐Liang Duan
• Keywords: 01 natural sciences; 0104 chemical sciences

AbstractA general and mild nickel‐catalyzed enantioselective C(sp2)−P cross‐coupling for synthesizing P‐stereogenic phosphine oxides has been developed. The asymmetric alkenylation/arylation of racemic secondary phosphine oxides with alkenyl/aryl bromides generated P‐stereogenic phosphine oxides with high yields and enantioselectivities. Various functional groups were tolerated, and the applications of this method were demonstrated through late‐stage functionalization and product transformations.