Light‐Activated Assembly of DNA Origami into Dissipative Fibrils

• DOI: 10.1002/ange.202314458
• Publication Date: 2023-10-31T03:37:02Z
• Authors: Willi R. Berg; Jonathan F. Berengut; Changzhuang Bai; Laura Wimberger; Lawrence K. Lee; Felix J. Rizzuto
• Keywords: DNA origami; DNA nanotechnology; Structural motif

Abstract Hierarchical DNA nanostructures offer programmable functions at scale, but making these structures dynamic, while keeping individual components intact, is challenging. Here we show that the A‐motif—protonated, self‐complementary poly(adenine) sequences—can propagate origami into one‐dimensional, micron‐length fibrils. When coupled to a small molecule pH regulator, visible light can activate hierarchical assembly of our dissipative This system recyclable and does not require modification. By employing modular waste‐free strategy assemble disassemble built from origami, facile accessible route developing well‐defined, large assemblies with temporal control. As general tool, envision coupling A‐motif cycles protonation will allow transient construction diverse nanostructures, finding broad applications in dynamic non‐equilibrium nanotechnology.