Cobalt‐Catalyzed Asymmetric Aza‐Nozaki–Hiyama–Kishi (NHK) Reaction of α‐Imino Esters with Alkenyl Halides

• DOI: 10.1002/ange.202316012
• Publication Date: 2024-01-02T09:09:19Z
• Authors: Tingting Xia; Yinhui Wu; Jiangtao Hu; Xianqing Wu; Jingping Qu; Yifeng Chen
• Keywords: Stereocenter

Abstract Chromium‐catalyzed enantioselective Nozaki–Hiyama–Kishi (NHK) reaction represents one of the most powerful approaches for formation chiral carbon‐heteroatom bond. However, construction sterically encumbered tetrasubstituted stereocenter through NHK still posts a significant challenge. Herein, we disclose cobalt‐catalyzed aza‐NHK ketimine with alkenyl halide to provide convenient synthetic approach manufacture enantioenriched α‐vinylic amino acid. This protocol exhibits excellent functional group tolerance 99 % ee in cases. Additionally, this asymmetric reductive method is also applicable aldimine access trisubstituted stereogenic centers.