Mechanochemical Iron‐Catalyzed Nitrene Transfer Reactions: Direct Synthesis of N‐Acyl Sulfonimidamides from Sulfinamides and Dioxazolones

• DOI: 10.1002/ange.202316702
• Publication Date: 2023-12-06T19:38:08Z
• Authors: Shulei Pan; Florian F. Mulks; Peng Wu; Kari Rissanen; Carsten Bolm
• Keywords: Nitrene; Chemoselectivity

Abstract A mechanochemical synthesis of sulfonimidamides by iron(II)‐catalyzed exogenous ligand‐free N ‐acyl nitrene transfer to sulfinamides is reported. The one‐step method tolerates a wide range with various substituents under solvent‐free ambient conditions. Compared its solution‐phase counterpart, this approach shows better conversion and chemoselectivity. Mechanistic investigations ESI‐MS revealed the generation crucial iron intermediates.