Proximity‐Enhanced Functional Imaging Analysis of Engineered Tumors

• DOI: 10.1002/ange.202319117
• Publication Date: 2024-02-02T15:53:34Z
• Authors: Tianshu Chen; Siwei Mao; Ji Ma; Xiaochen Tang; Rui Zhu; Dongsheng Mao; Xiaoli Zhu; Qiuhui Pan
• Keywords: Functional Imaging

Abstract Functional imaging (FI) techniques have revolutionized tumor by providing information on specific functions, such as glycometabolism. However, cells lack unique molecular characteristics at the level and metabolic pathways, resulting in limited differences compared to normal increased background signals from FI. To address this limitation, we developed a novel technique termed proximity‐enhanced functional (PEFI) for accurate visualization of tumors. By using “two adjacent chemically labeled glycoproteins” output signals, significantly enhance between PEFI, thereby reducing analysis improving accuracy imaging. Our results demonstrate that PEFI can accurately identify tumors cellular, tissue, animal level, has potential value clinical identification tissues, well guidance resection surgery.