Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

• DOI: 10.1002/ange.202413661
• Publication Date: 2024-08-22T02:53:36Z
• Authors: Ziyao Li; Binbin Ding; Jing Li; Hao Chen; Jiashi Zhang; Jia Tan; Xinyu Ma; Di Han; Ping'an Ma; Jun Lin
• Keywords: Ebselen

Abstract Single‐atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)‐mediated cancer therapy. However, the high energy barriers of reaction intermediates on single‐atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi‐enzyme mimetic MoCu dual‐atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme‐like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near‐infrared II bio‐window endows remarkable photothermal conversion performance. Consequently, achieves high‐efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic