Electrochemical Amino‐Oxygenation Cyclization via Alkene Radical Cation/Bisnucleophile Engagement to Saturated N/O‐Heterocycles

• DOI: 10.1002/ange.202501424
• Publication Date: 2025-03-12T00:06:12Z
• Authors: Shengzhang Liu; Hai Lin; Tianjiao Peng; Zhaoliang Yang; Pingnan Wan; Jiarong Li; Lingyun Yang; Xinglei Dai; Sichao Tu; Xiao Long; Aiwen Lei; Tao Wang; Hong Yi
• Keywords: Alkene; Radical ion; Radical cyclization

Regioselective functionalization of alkenes to create nitrogen‐ and oxygen‐containing heterocycles remains a significant challenge in organic synthesis. Due their unique electronic biological properties, these are crucial pharmaceuticals materials. Herein, we present an electrochemical amino‐oxygenation using alkene radical cations bisnucleophiles, enabling the synthesis saturated N/O‐heterocycles undivided cell. This method employs readily available amides alkenes, eliminating need for additional oxidants or redox catalysts. The situ generation results high yields with excellent regio‐ chemoselectivity. Our approach offers direct route six‐, seven‐, eight‐membered from simple starting materials, broadening access complex molecules essential medicinal chemistry materials science.