A Copper‐Catalyzed Tandem Synthesis of Indolo‐ and Pyrrolo[2,1‐a]isoquinolines

• DOI: 10.1002/anie.200804427
• Publication Date: 2008-12-31T19:12:47Z
• Authors: Akhilesh Kumar Verma; Tanay Kesharwani; Jaspal Singh; Vibha Tandon; Richard C. Larock
• Keywords: Isoquinoline; Tandem; Benzotriazole; Hydroxymethyl

Isoquinoline ring the changes: A novel strategy for title reaction involves ortho-haloarylalkynes which undergo sequential intermolecular addition of N heterocycles onto alkynes and subsequent intramolecular closure by arylation. The process use hydroxymethyl benzotriazole as an efficient inexpensive ligand CN CC coupling reactions.