Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine

• DOI: 10.1002/anie.201001853
• Publication Date: 2010-06-08T08:34:13Z
• Authors: Filippo De Simone; Jürg Gertsch; Jérôme Waser
• Keywords: Cyclopropanes; Antineoplastic Agents; Stereoisomerism; 01 natural sciences; Catalysis; Indole Alkaloids; 0104 chemical sciences; Alkaloids; Regioselectivity; Cyclization; Anticancer agents; Cell Line, Tumor; Quinolines; Humans; Heterocyclic compd; Drug Screening Assays, Antitumor; Catalytic Cyclization; Aminocyclopropanes

AbstractSelective cyclization of aminocyclopropanes at either the N1 or C3 position of an indole ring is achieved by tuning the reaction conditions.