Antioxidative Glutathione Peroxidase Activity of Selenoglutathione

• DOI: 10.1002/anie.201006939
• Publication Date: 2011-01-24T16:57:23Z
• Authors: Sari Yoshida; Fumio Kumakura; Itsuki Komatsu; Kenta Arai; Yuko Onuma; Hironobu Hojo; Beena G. Singh; K. Indira Priyada...; Michio Iwaoka
• Keywords: Selenocysteine; GPX3; GPX4; GPX1; GPX6

Pep talk: Selenoglutathione (GSeH) and other peptides containing selenocysteine with an amino acid sequence of the glutathione peroxidase (GPx) active site are obtained in oxidized form by solid-phase peptide synthesis. Their GPx activity against hydrogen peroxide (see picture) reveals that GSeH has effective antioxidant addition to biological function a analogue.