Characteristic Structural Parameters for the γ‐Peptide 14‐Helix: Importance of Subunit Preorganization

• DOI: 10.1002/anie.201101301
• Publication Date: 2011-05-12T15:53:27Z
• Authors: Li Guo; Weicheng Zhang; Andrew G. Reidenbach; Michael W. Giuliano; Ilia A. Guzei; Lara C. Spencer; Samuel H. Gellman
• Keywords: Folding (DSP implementation); Helix (gastropod); Substitution (logic); Residue (chemistry)

All wound up: Crystallographic data for a set of homologous peptides constructed from gabapentin and two to six preorganized γ-amino acid residues (see crystal structure the longest peptide) allow derivation characteristic parameters γ-peptide 14-helix establish guidelines characterizing 14-helical folding. The results suggest that substitution pattern γ-residue has profound effect on propensity Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note: publisher is responsible content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.