OsO4⋅Streptavidin: A Tunable Hybrid Catalyst for the Enantioselective cis‐Dihydroxylation of Olefins

• DOI: 10.1002/anie.201103632
• Publication Date: 2011-09-22T00:13:35Z
• Authors: Valentin Köhler; Jincheng Mao; Tillmann Heinisch; Anca Pordea; Alessia Sardo; Yvonne M. Wilson; Livia Knörr; Marc Creus; Jean‐Christophe P...; Tilman Schirmer; Thomas R. Ward
• Keywords: Dihydroxylation; Streptavidin

Taking control: Selective catalysts for olefin dihydroxylation have been generated by the combination of apo-streptavidin and OsO4. Site-directed mutagenesis allows improvement enantioselectivity even inversion enantiopreference in certain cases. Notably allyl phenyl sulfide cis-β-methylstyrene were converted with unprecedented enantiomeric excess. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The publisher is responsible content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.