Pellasoren: Structure Elucidation, Biosynthesis, and Total Synthesis of a Cytotoxic Secondary Metabolite from Sorangium cellulosum

• DOI: 10.1002/anie.201200327
• Publication Date: 2012-04-15T10:52:37Z
• Authors: Christine Jahns; Thomas Hoffmann; Stefan Müller; Klaus Gerth; Peter Washausen; Gerhard Höfle; Hans Reichenbach; Markus Kalesse; Rolf Müller
• Keywords: Secondary metabolite

Genetic analysis of biosynthetic gene clusters is becoming an accepted tool to predict the stereochemical outcome a biosynthesis. However, in case pellasoren, one chiral center was not predicted correctly. The absolute configuration verified by total synthesis, which also demonstrated that stereoselective protonations can be successfully applied natural products synthesis. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but copy-edited or typeset. They made available submitted authors. Please note: publisher responsible for content functionality any supporting information supplied Any queries (other than missing content) should directed corresponding author article.