Squaramides as Potent Transmembrane Anion Transporters

• DOI: 10.1002/anie.201200729
• Publication Date: 2012-03-29T14:01:52Z
• Authors: Nathalie Busschaert; Isabelle L. Kirby; Sarah Young; Simon J. Coles; Peter N. Horton; Mark E. Light; Philip A. Gale
• Keywords: Anions; Ion Transport; Molecular Structure; Hydrogen Bonding; 540; Amides; 01 natural sciences; Membrane Potentials; 3. Good health; 0104 chemical sciences; Chlorides; Phosphatidylcholines

Square peg in a round ball: Squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea urea analogues. Studies into nature of this transport point mobile carrier mechanism, where squaramide delivers cargo across lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide platform development new generation anion-transport systems. Detailed facts importance specialist readers published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note: The publisher is responsible content functionality any supporting information supplied Any queries (other missing content) should directed corresponding author article.