Multivalency as a Chemical Organization and Action Principle

• DOI: 10.1002/anie.201201114
• Publication Date: 2012-09-05T13:15:22Z
• Authors: Carlo Fasting; Christoph A. Scha...; Marcus Weber; Oliver Seitz; Stefan Hecht; Beate Koksch; Jens Dernedde; Christina Graf; Ernst‐Walter Knapp; Rainer Haag
• Keywords: Realization (probability); Non-covalent interactions

Abstract Multivalent interactions can be applied universally for a targeted strengthening of an interaction between different interfaces or molecules. The binding partners form cooperative, multiple receptor–ligand that are based on individually weak, noncovalent bonds and thus generally reversible. Hence, multi‐ polyvalent play decisive role in biological systems recognition, adhesion, signal processes. scientific practical realization this principle will demonstrated by the development simple artificial theoretical models, from natural to functional, application‐oriented systems. In systematic review scaffold architectures, underlying effects control options demonstrated, suggestions given designing effective multivalent systems, as well therapeutics.