Oxime Radical Promoted Dioxygenation, Oxyamination, and Diamination of Alkenes: Synthesis of Isoxazolines and Cyclic Nitrones

• DOI: 10.1002/anie.201203799
• Publication Date: 2012-07-24T20:20:24Z
• Authors: Bing Han; Xiu‐Long Yang; Ran Fang; Wei Yu; Chao Wang; Xiao‐Yong Duan; Shuai Liu
• Keywords: Vicinal

Up the tempo: The intramolecular addition of oxime radicals to CC bonds was achieved by using DEAD and TEMPO give 4,5-dihydroisoxazoles as a result CO bond-forming, 5-exo-trig cyclization. γ,δ-Unsaturated ketoximes also reacted afford cyclic nitrones through CN bond formation. reactions offer metal-free approach for vicinal difunctionalization unactivated alkenes. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: publisher is responsible content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.