Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence

• DOI: 10.1002/anie.201204087
• Publication Date: 2012-09-12T02:02:12Z
• Authors: Zhongli Xu; Martin Baunach; Ling Ding; Christian Hertweck
• Keywords: Terpene; Heterologous; Heterologous expression

Getting indole terpenes into shape: Genetic analysis, pathway dissection, and heterologous reconstitution provide first insights bacterial indolosesquiterpenoid biosynthesis unveil the involvement of a new type terpene cyclase an oxygenase in formation indosespene, xiamycin, sespenine ring systems. Furthermore, expression led to discovery CC- CN-linked xiamycin dimers. Detailed facts importance specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please note: The publisher is responsible for content functionality any supporting information supplied Any queries (other than missing content) should be directed corresponding author article.