Systemic Delivery of microRNA‐34a for Cancer Stem Cell Therapy

• DOI: 10.1002/anie.201208077
• Publication Date: 2013-03-01T08:06:27Z
• Authors: Sanjun Shi; Lu Han; Tao Gong; Zhirong Zhang; Xun Sun
• Keywords: Solid lipid nanoparticle

Delivered: A solid lipid nanoparticle (SLN) system was developed to deliver microRNA-34a (miR-34a) relevant for cancer stem cell (CSC) therapy into lung tissues. In miR-34a-containing SLNs (miSLNs-34a), miR-34a is protected from degradation in the serum and its cellular-transfection efficiency vitro increased. Thus, treatment with miSLNs-34a results a higher probability of survival CSC-bearing mice (see picture). As service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising (other than missing files) should addressed Please note: The publisher responsible content functionality any Any queries content) directed corresponding author article.