Synthesis of Stable Peptide Nucleic Acid‐Modified Gold Nanoparticles and their Assembly onto Gold Surfaces

• DOI: 10.1002/anie.201209684
• Publication Date: 2013-03-05T06:31:22Z
• Authors: Philipp Anstaett; Yuanhui Zheng; Thibaut Thai; Alison M. Funston; Udo Bach; Gilles Gasser
• Keywords: Peptide nucleic acid; Surface Modification

PNA does it better: Peptide nucleic acid (PNA) oligomers were attached to gold nanoparticles (AuNPs) through a variety of mono- and trithiol linkers. These functionalized particles had sufficient stability for sequence-specific self-assembly onto surfaces (see figure) in the absence ions or surfactants. The nanoparticle surface densities obtained superior comparable DNA-modified AuNPs.