Self‐Adjuvanting Synthetic Antitumor Vaccines from MUC1 Glycopeptides Conjugated to T‐Cell Epitopes from Tetanus Toxoid

• DOI: 10.1002/anie.201300390
• Publication Date: 2013-04-24T12:32:33Z
• Authors: Hui Cai; Mei‐Sha Chen; Zhan‐Yi Sun; Yu‐Fen Zhao; Horst Kunz; Yan‐Mei Li
• Keywords: Mucin-1; Glycopeptides; Epitopes, T-Lymphocyte; Cancer Vaccines; 01 natural sciences; 0104 chemical sciences; 3. Good health; Epitopes; Tetanus Toxoid; Epitopes, B-Lymphocyte; Humans; Peptides

The T-helper epitope peptide P30 (green in the scheme) from tetanus toxoid was used as the immunostimulant in MUC1 glycopeptide antitumor vaccines and apparently also acts as a built-in adjuvant. P30-conjugated glycopeptide vaccines containing three glycans in the immunodominant motifs PDTRP and GSTAP induced much stronger immune responses and complement dependent cytotoxicity mediated killing of tumor cells when applied in plain PBS solution without complete Freund's adjuvant.