Alkoxide Activation of Aminoboranes towards Selective Amination

• DOI: 10.1002/anie.201305098
• Publication Date: 2013-09-03T13:17:16Z
• Authors: Cristina Solé; Elena Fernández
• Keywords: Moiety; Pinacol; Alkoxide

Piece of the (inter)action: The interaction alkoxides with sp(2) Bpin (pin=pinacol) moiety in aminoboranes forms situ Lewis acid-base adduct [RO(-) →B(OR)2 N(R')2 ] which enables amino to react as a strong nucleophile several electrophiles, thus providing alcohols, β-enamino esters, and β-hydroxy amides direct remarkably selective way.