Synthesis of gem‐Difluorocyclopropa(e)nes and O‐, S‐, N‐, and P‐Difluoromethylated Compounds with TMSCF2Br

• DOI: 10.1002/anie.201306703
• Publication Date: 2013-09-12T17:03:25Z
• Authors: Lingchun Li; Fei Wang; Chuanfa Ni; Jinbo Hu
• Keywords: Difluorocarbene

Two-in-one: Me3 SiCF2 Br is an efficient difluorocarbene source and compatible with both neutral aqueous basic conditions. Bromide-ion-initiated [2+1] cycloaddition alkenes/alkynes hydroxide ion promoted α-addition (thio)phenols, (thio)alcohols, sulfinates, heterocyclic amines, H-phosphine oxides give the corresponding gem-difluorinated compounds broad functional-group tolerance.