Palladium‐Catalyzed Regioselective Diarylation of o‐Carboranes By Direct Cage B−H Activation

• DOI: 10.1002/anie.201507697
• Publication Date: 2015-10-14T11:42:48Z
• Authors: Yangjian Quan; Zuowei Xie
• Keywords: Cage

Abstract Palladium‐catalyzed intermolecular coupling of o ‐carborane with aromatics by direct cage B−H bond activation has been achieved, leading to the synthesis a series B(4,5)‐diarylated‐ ‐carboranes in high yields excellent regioselectivity. Traceless directing group ‐COOH plays crucial role for site‐ and di‐selectivity such reaction. A Pd II –Pd IV catalytic cycle is proposed be responsible stepwise arylation.