Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non‐UV‐Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method

• DOI: 10.1002/anie.201509460
• Publication Date: 2015-11-23T12:30:35Z
• Authors: Bruno Linclau; Zhong Wang; Guillaume Compain; Vincent Paumelle; Clement Q. Fonten...; Neil Wells; Alex Weymouth‐Wilson
• Keywords: Lipophilicity

Property tuning by fluorination is very effective for a number of purposes, and currently increasingly investigated aliphatic compounds. An important application lipophilicity (log P) modulation. However, the determination log P cumbersome non-UV-active A new variation shake-flask method presented, enabling measurement fluorinated compounds with or without UV activity regardless whether they are hydrophilic lipophilic. No calibration curves measurements compound masses/aliquot volumes required. With this method, influence on alcohols was determined, values carbohydrates were measured. Interesting trends changes, example, dependence relative stereochemistry, reported.