Decarboxylative Alkyl–Alkyl Cross‐Coupling Reactions

• DOI: 10.1002/anie.201605593
• Publication Date: 2016-07-15T12:20:57Z
• Authors: Mikhail O. Konev; Elizabeth R. Jarvo
• Keywords: Negishi coupling; Beta-Hydride elimination; Coupling reaction

Alkyl with alkyl: A significant development in alkyl-alkyl cross-coupling reactions, namely the nickel-catalyzed decarboxylative Negishi coupling of N-hydroxyphthalimide esters, was recently reported by Baran and co-workers. This method enables synthesis various highly functionalized compounds, including natural product derivatives.