Yttrium‐Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium‐Sized Lactams

• DOI: 10.1002/anie.201700596
• Publication Date: 2017-03-07T13:58:41Z
• Authors: Bo Zhou; Long Li; Xin‐Qi Zhu; Juan‐Zhu Yan; Yi‐Lin Guo; Long‐Wu Ye
• Keywords: Sequence (biology)

An efficient yttrium-catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium-sized lactams. Furthermore, mechanistic rationale for this novel cascade reaction is well supported by variety control experiments.