Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid

• DOI: 10.1002/anie.201703127
• Publication Date: 2017-05-24T01:03:30Z
• Authors: He Huang; Chenguang Yu; Xiangmin Li; Yongqiang Zhang; Yueteng Zhang; Xiaobei Chen; Patrick S. Mariano; Hexin Xie; Wei Wang
• Keywords: Glyoxylic acid; Formylation; Boronic acid

Abstract Reported herein is a conceptually novel organocatalytic strategy for the formylation of boronic acids. New reactivity engineered into α‐amino‐acid‐forming Petasis reaction occurring between aryl acids, amines, and glyoxylic acids to prepare aldehydes. The operational simplicity process its ability generate structurally diverse valued aryl, heteroaryl, α,β‐unsaturated aldehydes containing wide array functional groups, demonstrates practical utility new synthetic strategy.