Spatio‐Temporally Reporting Dose‐Dependent Chemotherapy via Uniting Dual‐Modal MRI/NIR Imaging

• DOI: 10.1002/anie.202009380
• Publication Date: 2020-07-30T17:33:48Z
• Authors: Yiyu Ma; Chenxu Yan; Zhiqian Guo; Guang Tan; Dechao Niu; Yongsheng Li; Wei‐Hong Zhu
• Keywords: Dicumarol; Dose-Response Relationship, Drug; Molecular Structure; Cell Survival; Hydroxyl Radical; Infrared Rays; Iron; Mice, Nude; Antineoplastic Agents; Hydrogen Peroxide; Neoplasms, Experimental; Magnetic Resonance Imaging; Mice; A549 Cells; NAD(P)H Dehydrogenase (Quinone); Animals; Humans; Magnetic Iron Oxide Nanoparticles; Drug Screening Assays, Antitumor; Cell Proliferation

Unpredictable in vivo therapeutic feedback of hydroxyl radical (. OH) efficiency is the major bottleneck chemodynamic therapy. Herein, we describe novel Fenton-based nanotheranostics NQ-Cy@Fe&GOD for spatio-temporally reporting intratumor . OH-mediated treatment, which innovatively unites dual-channel near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI) signals. Specifically, MRI signal traces dose distribution iron oxide nanoparticles (IONPs) with high-spatial resolution, meanwhile timely quantifies response high spatio-temporal resolution. can successfully monitor intracellular release IONPs OH-induced NQO1 enzyme living cells tumor-bearing mice, makes a breakthrough conquering inherent unpredictable obstacles on therapy, so as to manipulate dose-dependent process.