In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

• DOI: 10.1002/anie.202012512
• Publication Date: 2020-10-08T03:04:41Z
• Authors: Xiaomei Wang; Lei Chen; Zhuanling Bai; Duo Zhang; Jingwen Guan; Yijing Zhang; Cen Shi; Juan Diwu
• Keywords: Animals; Nanoparticles; Uranium; Cattle; 01 natural sciences; Metal-Organic Frameworks; 0104 chemical sciences

An agent for actinide sequestration with fast uranium uptake kinetics and efficient in vivo removal using a nanoscale metal-organic framework (nano-MOF) is proposed. UiO-66 nanoparticles post-synthetically functionalized carboxyl groups, UiO-66-(COOH)4 -180, exhibit the fastest reported more than 65 % of uranyl fetal bovine serum (FBS) removed within 5 min. Moreover, bio-distribution studies show that material partially accumulates kidneys femurs where mainly deposits facilitating uranium. The results decorporation assays mice -180 could successfully reduce amounts deposited by up to 55.4 36.5 %, respectively, significantly commercial agent, ZnNa3 -DTPA.