Self‐Reporting Activated Ester‐Amine Reaction for Enantioselective Multi‐Channel Visual Detection of Chiral Amines

• DOI: 10.1002/anie.202202268
• Publication Date: 2022-03-14T13:42:10Z
• Authors: Sheng Wang; Siyu Xie; Hua Zeng; Hongxu Du; Jie Zhang; Xinhua Wan
• Keywords: Luminescence; Circular Dichroism; Esters; Stereoisomerism; Amines

Abstract Chiral recognition is of importance not only in living systems but also estimating the optical purity enantiomeric drugs and fabricating advanced materials. Herein we report a novel self‐reporting activated ester‐amine reaction that can provide multi‐channel visual detection organic amines. It relies on extent dependent cis‐transoid to cis‐cisoid helical transition polyphenylacetylene backbone thus triggered fluorescence. Owing high selectivity, this process recognize structurally diverse achiral amines quantitatively check impurity content. shows an outstanding enantioselectivity towards various chiral be applied determine composition. The multiple responses absorption, circular dichroism, photoluminescence, circularly polarized luminescence make polymer potential mode for high‐throughput screening chemicals.