Fast‐Scanning Potential‐Gated Organic Electrochemical Transistors for Highly Sensitive Sensing of Dopamine in Living Rat Brain

• DOI: 10.1002/anie.202204134
• Publication Date: 2022-05-18T12:12:00Z
• Authors: Weiqi Li; Jing Jin; Tianyi Xiong; Ping Yu; Lanqun Mao
• Keywords: 0301 basic medicine; Neurotransmitter Agents; 0303 health sciences; 03 medical and health sciences; Dopamine; Animals; Brain; Reproducibility of Results; Electrochemical Techniques; Rats

Developing techniques for the highly sensitive assay of neurotransmitters is essential understanding physiological and pathological processes. Here, we demonstrate a fast-scanning potential (FSP)-gated organic electrochemical transistor (OECT): sensing dopamine (DA) in living rat brain. The configuration combines selectivity fast-scan cyclic voltammetry (FSCV) with high sensitivity an OECT. combined use FSP as gating mode transconductance (gm ) parameter further improve performance terms sensitivity, limit detection, reproducibility, stability. FSP-OECT exhibits 0.899 S M-1 low detection down to 5 nM was validated vivo monitoring basal level electrically stimulated release DA.